FESPIXON® Cream

Brand Name

FESPIXON^® Cream

Indications

Diabetic Foot Ulcers (DFU)

Mechanism of Action

Inhibits inflammation
Regulates the generation of collagen
Promotes the regeneration of damaged cells
Promotes the proliferation of human keratinocytes
Reduce inflammatory M1 macrophages, stimulate adipose precursor cells to secrete GCSF and CXCL3, and increase repairing M2a/M2c macrophages, thereby promote complete wound healing. The mechanism of action studies can be referred to JID Innovations (2022).

Taiwan FDA Approval Number

060827

Singapore HSA Approval Number

SIN16683P

Malaysia NPRA Approval Number

MAL23076025B

China NMPA Approval Number

ZC20230001 (Approved generic name: Xianglei Tangzu Gao)

Indonesia BPOM Approval Number

POM TI 247049901

Research Publication/ Abstract

More Infromation

You are encouraged to report negative side effects of prescription drugs to:
Phone: 0800-258-688
Mail: PV.PMS@onenessbio.com.tw

Prescription medications must be used only under the direction of a licensed physician. If you have any health concerns, please seek medical advice from a qualified healthcare provider. Find the closest hospital for medical care.

Package Insert Download

Mechanism of Action

Novel Mechanism Promotes Healing by Regulating M1/M2 Macrophages and Rebalancing the Wound Microenvironment

Inhibit pro-inflammatory M1 φ and stimulate adipose precursor cells to secrete GCSF and CXCL3 to increase repairing M2a/M2c φ

Reference: Restoring Pro-healing/remodeling-associated M2a/c Macrophages using ON101 Accelerates Diabetic Wound Healing, JID Innovations (2022);2:100138, doi: https://doi.org/10.1016/j.xjidi.2022.100138.

Superior Efficacy to Current Standard Care

Reference: Effect of a Novel Macrophage-Regulating Drug on Wound Healing in Patients With Diabetic Foot Ulcers, JAMA Netw Open. 2021;4(9):e2122607, doi:10.1001/jamanetworkopen.2021.22607.